A research team led by Prof. GUO Yusong, Associate Professor of the Division of Life Science at The Hong Kong University of ...

Scientists are testing a strikingly simple idea for calming some of the brain’s most stubborn seizures: remove the aging ...

Tears seem simple, but the tiny glands that produce them are among the least understood organs in the human body. By growing ...

The plausible mechanism pathway “could accelerate gene therapy/editing development,” analysts at William Blair said Thursday, while adding that additional clarity is needed. Individualized therapies ...

Osaka, Japan – Our cells carry out hundreds of thousands of important functions every day, all of which are carefully orchestrated at a microscopic scale. However, the precise mechanisms that ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

Lysosomes are dynamic organelles integral to cellular homeostasis, secretory pathways, immune responses, and cell death regulation. In cancers, lysosomes become dysregulated to sustain proliferative ...

A novel reporter protein has been developed to enable the investigation of protein biogenesis in the ER and its disruption in disease. A recent research collaboration between multiple Japanese ...

Introduction: Vascular inflammation is a major component in the pathogenesis of pulmonary arterial hypertension (PAH). Inflammatory mediators initiate a pro-inflammatory state in capillary-resident ...

Neuropeptides and neurotrophins are stored in and released from dense core vesicles (DCVs). While DCVs and synaptic vesicles (SVs) share fundamental SNARE/SM proteins for exocytosis, a detailed ...