Abstract: Advances in deep generative models shed light on de novo molecule generation with desired properties. However, molecule generation targeted for dual protein targets still faces formidable ...

Harmony Biosciences Holdings, Inc. (Nasdaq: HRMY), today announced the presentation of initial open-label extension (OLE) data from the company’s ongoing Phase 3 ARGUS trial investigating EPX-100 ...

Background/aim: 5-Hydroxytryptamine (5-HT) released from enterochromaffin cells influences intestinal homeostasis by altering gut physiology and is implicated in the pathophysiology of various gut ...

The report also covers products from therapy areas such as Central Nervous System, Cardiovascular, Respiratory, and Immunology which include the indications Autism Spectrum Disorder (ASD), Alzheimer’s ...

The report also covers products from therapy areas such as Central Nervous System, Undisclosed, Metabolic Disorders, and Women’s Health which include the indications Unspecified Psychiatric Disorders, ...

Abstract: Accurate prediction of drug-target interactions (DTIs) is essential for advancing drug discovery and repurposing. However, the sparsity of DTI data limits the effectiveness of existing ...

aDepartment of Radiation Oncology and James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA bDepartment of Biostatistics and James P Wilmot Cancer ...

Serotonin is an example of a neurotransmitter, a chemical messenger that is passed between nerve cells. When a nerve impulse reaches the axon at the end of a nerve, neurotransmitters are released ...

Post-stroke depression (PSD) is the most common and serious sequelae of stroke. Approximately 33% of stroke survivors were affected by PSD. However, many issues (e.g., incidence, diagnostic marker, ...

1 Department of Infectious Diseases, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China 2 Department of Postgraduate, Xi’an Medical University, Xi’an, China This study included ...