Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

Walter Nolen III, a defensive tackle out of Ole Miss, was scouted by the 49ers, who instead took Mykel Williams with the No. 11 pick in the first round. Nolen went to the Cardinals at No. 16 and didn’t make his debut until two weeks ago because of a late-July calf injury.

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from November 16, 2025 on ESPN.

The San Francisco 49ers are already without Fred Warner, and they may have lost another linebacker early against the Arizona Cardinals on Sunday.

Kyle Shanahan shared the San Francisco 49ers’ worries about Eddy Piñeiro’s hamstring injury after his early exit against the Arizona Cardinals.

With the defense and special teams coming up with big plays, the 49ers dominate Cardinals in Brock Purdy’s return.

Following a Loss This Season

San Francisco 49ers running back Christian McCaffrey scores his third touchdown of the game against the Arizona Cardinals with a 4-yard run.