The last time star wide receiver Brandon Aiyuk and the San Francisco 49ers took on the Kansas City Chiefs, it did not go swimmingly. It was no better on Sunday.

The Chiefs, like the 49ers with Christian McCaffrey, have been missing their own starting running back all season. Isiah Pacheco had leg surgery in mid-September and could return six-to-eight weeks after that procedure. Kansas City is also missing wide receivers Hollywood Brown and Rashee Rice, the latter of whom had knee surgery last week.