Verastem Oncology , a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced that following evaluation of interim data from ...
Skin aging manifests as structural degradation, functional decline, and heightened disease susceptibility. Central to this process is the overactivation of the mitogen-activated protein kinase (MAPK) ...
1 Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China 2 Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang ...
NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...
Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Therefore, building on prior findings and the existing ...
The tumor suppressor pVHL can augment or repress pathways to activate or repress transcription factors. This regulation is important for controlling the microenvironment, proliferation, and cell fate.
With the FDA clearance of an investigational new drug application, a phase 1 clinical trial evaluating NST-628 will start in mid-2024. NST-628 is a new investigational drug for patients with advanced ...
Rat aortic SMCs were prepared from thoracic aortas of 2- to 3-month-old Sprague-Dawley rats by the explant technique. 14 The cells were cultured in DMEM containing 10% FBS, 150 mmol/L HEPES, 100 U/mL ...
Rationale: Activation of p38 mitogen-activated protein kinase (MAPK) has a significant impact on cardiac gene expression, contractility, extracellular matrix remodeling, and inflammatory response in ...
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