Harmony Biosciences Presents Clinically Meaningful Open-Label Extension Study Effectiveness Data for EPX-100 in Dravet Syndrome

Harmony Biosciences Holdings, Inc. (Nasdaq: HRMY), today announced the presentation of initial open-label extension (OLE) data from the company’s ongoing Phase 3 ARGUS trial investigating EPX-100 ...
Nature

Subcellular Localization of 5-Hydroxytryptamine and Histamine in Blood Platelets

Da Prada, M., Tranzer, J. P., and Pletscher, A., J. Pharmacol. Exp. Therap (in the press). Tranzer, J. P., Da Prada, M., and Pletscher, A., in Advances in ...
IEEE

A Unified Conditional Diffusion Framework for Dual Protein Targets-Based Bioactive Molecule Generation

Abstract: Advances in deep generative models shed light on de novo molecule generation with desired properties. However, molecule generation targeted for dual protein targets still faces formidable ...
C&EN

Development, Validation, and Use of Quantitative Structure−Activity Relationship Models of 5-Hydroxytryptamine (2B) Receptor Ligands to Identify Novel Receptor Binders and ...

† Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States ‡ National Institute of Mental ...
Nature

Depression and anxiety in Parkinson disease

Evidence suggests that both anxiety and depression might have pathophysiological links with Parkinson disease (PD), as these mood disorders are more prevalent in individuals with PD than in patients ...