Nonalcoholic fatty liver disease refers to a spectrum of diseases from hepatic steatosis to NASH, a condition where fat accumulation causes inflammation and hepatocyte injury leading to cirrhosis. [1] ...

Obstructive sleep apnea (OSA) is characterized by partial or complete airway obstruction during sleep. Prevalence is about 1.2%. [1] [1] Adenotonsillar hypertrophy and obesity are common risk factors ...

Smoking marijuana can increase clearance of some drugs Smoked marijuana increases the clearance of theophylline 40%. 1 Similar findings would be expected for other drugs metabolized by CYP1A2, such as ...

Background: Fragility fractures are a major health concern for older adults and can result in disability, admission to hospital and long-term care, and reduced quality of life. This Canadian Task ...

Background: Cancer surveillance data are essential to help understand where gaps exist and progress is being made in cancer control. We sought to summarize the expected impact of cancer in Canada in ...

KEY POINTS In 2016, 270 204 people in Canada (excluding Quebec) were admitted to hospital for heart conditions, stroke and vascular cognitive impairment, including 107 391 women and 162 813 men, of ...

Iron deficiency and iron deficiency anemia are common during pregnancy and are associated with adverse outcomes Prenatal iron deficiency occurs in more than 30% of pregnancies in Canada. 1 It has been ...

Background: Pharmacogenomic testing to identify variations in genes that influence metabolism of antidepressant medications can enhance efficacy and reduce adverse effects of pharmacotherapy for major ...

Major hemorrhage is a challenging clinical problem that can occur with traumatic injury, postpartum hemorrhage, major surgery and gastrointestinal bleeding. A massive hemorrhage protocol (MHP) should ...

Recreational use of nitrous oxide is a growing problem in many jurisdictions, including Canada. Although isolated, short-term use rarely leads to serious complications, chronic use can cause ...

A 51-year-old woman was referred to the rheumatology department with a 2-month history of edematous hands. She had been experiencing Raynaud phenomenon for the past 5 years but her personal and family ...

Falls are the leading cause of injury-related hospital admissions and deaths among older adults (aged ≥ 65 yr) About 30% of older adults report a fall each year, and about 20% experience a ...