EurekAlert!

SOX9 overexpression ameliorates metabolic dysfunction-associated steatohepatitis through activation of the AMPK pathway

Our findings demonstrate that SOX9 overexpression alleviates hepatic lipid accumulation in MASH by activating the AMPK pathway. These results highlight SOX9 as a promising therapeutic target for ...
News Medical

New redox-sensitive pathway reveals how cells activate AMPK in response to metabolic stress

AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress. While upstream activation by the kinase LKB1 is well recognized, the ...
EurekAlert!

DDAH1 controls hepatic lipid metabolism under fasting

The liver plays a central role in maintaining systemic energy homeostasis during fasting by mobilizing lipid reserves, a ...
ascopubs.org

Use of proteomic analysis of LKB1/AMPK/mTOR pathways to identify IGF-1R pathway upregulation with LKB1 loss or mTOR inhibition in NSCLC: Implications for targeted combinations.

Evaluation of EZH2 SNPs in cholangiocarcinoma patients. This is an ASCO Meeting Abstract from the 2012 ASCO Annual Meeting I. This abstract does not include a full text component.
GEN

Energy Regulator AMPK’s Role in Neuronal Survival

This graphic illustration of a study in Cell Reports shows how a molecular energy regulator in cells, AMPK, is required for astrocytic glycoses, lactate production and lactate shuttle to bio-energize ...