Substance use and substance use disorder (formerly substance abuse) differ by the frequency of use and the effect on a person's life. Learn more.

Medically reviewed by Michael MacIntyre, MD Substance use disorder (SUD) is a medical condition that affects the brain and behavior, making it difficult for a person to control their use of substances ...

There is a very close relationship between depression and substance abuse in adults. The two conditions are highly comorbid, which is to say that they occur together in an extremely high ...

Learn whether Abilify is a controlled substance and why or why not.