Detroit's injury misfortunes continued and the final injury report has several top players on it including Pro Bowl players.

"He’s probably grown more than anybody has throughout the year, as far as our young guys. He’s grown the most," Lions coach Dan Campbell said. "What you love about him is why he’s here. Of course, he’s got ability, but he’s smart, he’s instinctive, he’s tough, he’s a finisher, he’s resilient.

The Chicago Bears held their last practice Friday before their season finale against the Detroit Lions and the start of the NFL playoffs.

Detroit Lions wide receiver Jameson Williams (1) celebrates with wide receiver Amon-Ra St. Brown after St. Brown scored a touchdown during the week 12 matchup on Sunday, Nov. 23, 2025 at Ford Field in Detroit. (Jake May | MLive.com)

Pregame analysis and predictions of the Detroit Lions vs. Chicago Bears NFL game to be played on January 4, 2026 on ESPN.

Alex Anzalone, who suffered a brain injury in last week's loss to the Minnesota Vikings, won't play against the Bears for personal reasons.

Why is this relevant? The Cowboys are the only team that both the Cardinals and Lions have beaten in some time. The Arizona Cardinals have lost 13 of their last 14 games. The Detroit Lions have lost 4 of their last 5 games. The Cowboys are the one win for both of them.

The Detroit Lions have officially ruled out five players against the Chicago Bears. On the injury designation report, right tackle Penei Sewell, defensive tackle Alim McNeill, offensive lineman Trystan Colon, safety Thomas Harper and linebacker Alex Anzalone were ruled out.

"And you can have a system all you want, but it’s whatever dictates that week is necessary to win the football game. And that’s predicated on a lot of different variables.”

Sam: Revenge spot. The Vikings absolutely dominated the Lions at the line of scrimmage, something the Bears aren’t equipped to do. Wrap up the RBs and blitz Goff to get him uncomfortable. The Lions’ defense is decimated and the Bears can find passing lanes and running room. Cap off the season for the home fans and get out healthy.

Those that could be quite close include Bears assistant GM Ian Cunningham, Colts assistant GM Ed Dodds, Bills assistant GM Terrance Gray, Eagles assistant GM Alec Halaby and Packers VP of player personnel Jon-Eric Sullivan. Prior to the 2025 season, Agnew had positive thoughts about the upcoming 2025 season.