G protein coupled receptors (GPCRs) are essential drug targets for therapeutic intervention due to their integral roles in a plethora of fundamental signal transduction pathways. Indeed, GPCRs have a ...

Michael J. Capper is in the Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA. Daniel Wacker is in the Department of Pharmacological ...

After Jonathan Violin completed his Ph.D. at the University of California, San Diego, he wanted to continue his research with a high-profile scientist working on G-protein-coupled receptors (GPCRs).

NEW YORK, NY (April 27, 2022)--Roughly a third of all drugs approved by the U.S. Food and Drug Administration target a large family of biomolecules, known as G protein-coupled receptors (GPCRs), whose ...

G-protein coupled receptors (GPCRs) are seven-pass transmembrane proteins involved in numerous signaling pathways. Upon extracellular ligand binding and activation, members of this superfamily mediate ...

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are ...

Then, on Aug. 4, 2000, structural biologists published the first X-ray structure of a GPCR. That day, an elated Topiol charged into a meeting, the journal article held aloft. “It was all very exciting ...

PENZBERG, Germany--(BUSINESS WIRE)-- G-coupled protein receptors (GPCRs), also known as 7-transmembrane proteins, constitute the single largest class of therapeutic targets for clinical and ...

A group of researchers has identified the cause of a 'short-circuit' in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases and could lead to development ...