JSTOR Daily

Amyloid β-Peptide Inhibition of the PKA/CREB Pathway and Long-Term Potentiation: Reversibility by Drugs That Enhance cAMP Signaling

Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 20 (Oct. 1, 2002), pp. 13217-13221 (5 pages) Changes in hippocampal function seem critical for cognitive ...
GEN

Evidence Found that CREB Pathway Is More Complex than Previously Thought

Scientists observed that CREB activates specific genes based on the co-factor involved. Investigators at St. Jude Children’s Research Hospital discovered how a transcription factor called CREB ...
Nature

Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance

Multiple drug resistance is a challenging issue in the clinic. There is growing evidence that the G-protein-coupled estrogen receptor (GPER) is a novel mediator in the development of multidrug ...
EurekAlert!

Bear bile powder inhibits the release of NLRP3 by activating the cAMP/PKA/CREB signaling pathway to treat dextran sulfate sodium-induced colitis in mice

BBPH, bear bile powder high dose; BBPL, bear bile powder low dose; DSS, dextran sulfate sodium; NC, normal control; 5-ASA, 5-Amino salicylic acid. Ulcerative colitis (UC) is a chronic autoimmune ...
EurekAlert!

Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways

Mitogen-activated protein kinase (MAPK) and Wnt signaling pathways are critical for melanocyte development and melanogenesis and could be novel therapeutic targets for modulating melanin synthesis.