The release of protein structure predictions from AlphaFold will increase the number of protein structural models by almost three orders of magnitude. Structural biology and bioinformatics will never ...

Advances in structural biology have allowed scientists to determine molecular structures with atomic-level detail, sometimes yielding static snapshots that do not reflect the dynamism of proteins.

The alternative text for this image may have been generated using AI. In this Review, we discuss the key types of non-B DNA structure with a focus on their roles in genetic instability and disease ...

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Many bacterial cells defend themselves against antibiotics by expelling the drugs using multidrug efflux pumps. Unlike many other transporters, which only work with single compounds, such protein ...

AlphaFold 3, unveiled to the world on May 9, is the latest version of an algorithm designed to predict the structures of proteins – vital molecules used by all life – from the “instruction code” in ...

Researchers have deposited over 6,300 protein structures in a freely available database. The models result from protein structure predictions completed by David Baker’s group at the University of ...

As people around the world marveled in July at the most detailed pictures of the cosmos snapped by the James Webb Space Telescope, biologists got their first glimpses of a different set of images — ...

Proteins mediate the critical processes of life and beautifully solve the challenges faced during the evolution of modern organisms. Our goal is to design a new generation of proteins that address ...

Human cells are extremely small and tightly packed – at about 20 micrometers across, roughly one-fifth the width of a human hair, each cell contains a dense mix of proteins, organelles, and molecular ...

Northwestern Medicine scientists have discovered that little-studied DNA structures play a central role in organizing the human genome and controlling gene activity, according to a new study published ...