image: A series of amines, including synthetic challenging primary amines were synthesized with highly tolerance of other reducible functional groups. Mechanistic studies from control experiments and ...

Chemical structure of imatinib, a precision cancer drug containing an amide bond. Xiaoguang Lei and his team used their engineered enzyme to streamline the synthesis of imatinib, a landmark cancer ...

A high-yield, one-pot, scalable reaction facilitates the production of biologically relevant amide compounds using less reactive nitrogen-containing heterocyclic compounds and carboxylic acid without ...

Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example, making ...

A single type of chemical structure that shows up again and again in modern medicine is the amide bond that links a carbonyl group (C=O) to a nitrogen atom. They're so ubiquitous that 117 of the top ...