AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress. While upstream activation by the kinase LKB1 is well recognized, the ...
Activating the PPARβ/δ-AMPK metabolic pathway could be an effective strategy to tackle the most common chronic liver disease in the world’s population. A study led by Manuel Vázquez Carrera, group ...
Our findings demonstrate that SOX9 overexpression alleviates hepatic lipid accumulation in MASH by activating the AMPK pathway. These results highlight SOX9 as a promising therapeutic target for ...
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