Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

The San Francisco 49ers are already without Fred Warner, and they may have lost another linebacker early against the Arizona Cardinals on Sunday.

Wide receiver Skyy Moore returned the opening kickoff 98 yards and running back Christian McCaffrey got the final yard the Niners needed for a touchdown one play later. That made it 7-0 with 16 seconds off the clock in Arizona.

The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday at State Farm Stadium.

The Arizona Cardinals play host to the San Francisco 49ers in Week 11 NFL action. Both teams move into this week hoping to rebound in a massive way

The San Francisco 49ers open the game with a 98-yard kick return and running back Christian McCaffrey caps off the drive on the first play with a 1-yard rushing touchdown on the road against the Arizona Cardinals in the first 13 seconds of the game.

The San Francisco 49ers are on the road against the Arizona Cardinals. A blowout feels too good to be true. The Cardinals are a divisional opponent who just gave up 44 points. The Niners should expect the best effort from Arizona today, especially at home.

The Arizona Cardinals take on the San Francisco 49ers on Sunday at State Farm Stadium, kicking off at 4:05 p.m. ET (2:05 p.m. ET). The Cardinals are 3.5-point underdogs in this game. They are 1-6 in their last seven games and lost to the 49ers once already this season.

Oct 6, 2024; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) gestures after a catch against the Arizona Cardinals during the fourth quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images / Darren Yamashita-Imagn Images

The 49ers quarterback is making his first start since Week 4 and he has his first touchdown pass since returning to action. Purdy hit tight end George Kittle with a 30-yard bomb to give the 49ers a 13-0 lead with 9:51 to play in the first quarter.