As the Panthers try to beat out the Buccaneers for the NFC South, Carolina has added some extra defensive depth.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

Carolina has a chance to break back into the conversation, and the playoff picture with a win over the 49ers tonight.

The 49ers improved to 8-4 overall and 8-2 in NFC competition, with their growing bond next tested Sunday in Cleveland.

If the 49ers make the playoffs McCaffrey might start to feel the effects of the 400-plus touches he’s on pace for, but that’s a concern for down the road.

This will surely put them over the top. The Carolina Panthers have announced a pair of moves going into tonight's game with the San Francisco 49ers on ESPN's presentation of Monday Night Football. The Panthers are 6-5 and have a chane to take first place in the NFC South thanks to Tampa's loss to the Los Angeles Rams last night.

NFL Week 13 odds, picks, predictions, TV channel, streaming information for Sunday football game between the Los Angeles Rams and Carolina Panthers.

The NFL suspended Panthers safety Tre'von Moehrig for one game without pay following unsportsmanlike conduct that occurred Monday night in Carolina's 20-9 loss to the San Francisco 49ers. In the fourth quarter,

The inconsistent play of quarterback Bryce Young and the offense is holding the Carolina Panthers back from being a playoff team. Eight days after Young threw for a franchise record 448 yards and three touchdowns in a road win at Atlanta,